Cdc25A Antibody

• Background:

  CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated.

• NCBI Gene ID:

  993

• Swiss Prot:

  P30304

• Accession Number:

  P30304

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This Cdc25A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-300 amino acids from the Central region of human Cdc25A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  59 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CDC25A

• NCBI Official Name:

  M-phase inducer phosphatase 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ito, Y., et al., Int. J. Mol. Med. 13 (3) :431-435 (2004) .

• Background Reference 02:

  Nemoto, K., et al., Prostate 58 (1) :95-102 (2004) .

• Background Reference 03:

  Goloudina, A., et al., Cell Cycle 2 (5) :473-478 (2003) .

• Background Reference 04:

  Chen, M.S., et al., Mol. Cell. Biol. 23 (21) :7488-7497 (2003) .

• Other Product Names:

  M-phase inducer phosphatase 1, Dual specificity phosphatase Cdc25A, CDC25A

• Tested Applications:

  WB, IHC-P

• Protein ID:

  50403734

• Physical Properties:

  Liquid