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GREMLIN Antibody

CAT: 0223-62-135Size: 400 µLDry Ice: NoHazardous: No
CAT#: 62-135Size: 400 µL
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
GREMLIN is a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth.
NCBI Gene ID
23892
Swiss Prot
O70326
Accession Number
O70326
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This GREMLIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-175 amino acids from the C-terminal region of mouse GREMLIN.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
21 kDa
Fragment
Rabbit Ig
Symbol
Grem1
NCBI Official Name
Gremlin-1
NCBI Organism
Mus musculus
Background Reference 01
Chen, B., et al., J. Immunol. 173 (10) :5914-5917 (2004) . Chen, B., et al., Biochem. Biophys. Res. Commun. 295 (5) :1135-1141 (2002) . McMahon, R., et al., J. Biol. Chem. 275 (14) :9901-9904 (2000) . Murphy, M., et al., J. Biol. Chem. 274 (9) :5830-5834 (1999) . Hsu, D.R., et al., Mol. Cell 1 (5) :673-683 (1998) .
Other Product Names
Gremlin-1, Cysteine knot superfamily 1, BMP antagonist 1, Down-regulated in Mos-transformed cells protein, Grem1, Cktsf1b1, Drm
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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