Gremlin Recombinant Protein

• Background:

  Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.

• NCBI Gene ID:

  26585

• Swiss Prot:

  O60565

• Accession Number:

  NP_037504

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Chemokines & Cytokines, Growth Factors

• Buffer:

  PBS, pH7.4 with 1 mM EDTA

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  20.2 kDa

• Applications Notes:

  This recombinant protein can be used for E, WB. For research use only.

• NCBI Official Name:

  Gremlin-1 isoform 1 precursor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  McMahon R., et al., 2000, J. Biol. Chem. 275:9901-9904.

• Background Reference 02:

  Topol L.Z., et al., 2000, Cytogenet. Cell Genet. 89:79-84.

• Background Reference 03:

  Jaeger E., et al., 2012, Nat. Genet. 44:699-703.

• Other Product Names:

  GREM1, CKTSF1B1, DAND2, DRM, PIG2

• Tested Applications:

  ELISA, WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3