Gremlin-1 Recombinant Protein

CAT: 0223-40-594-01Size: 0.01 mgDry Ice: NoHazardous: No
CAT#:0223-40-594-01Size:0.01 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Gremlin-1 (isoform-1) belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Gremlin is highly expressed in the small intestine, fetal brain, and colon and lower expression in brain, prostate, pancreas and skeletal muscle. Gremlin-1 regulates multiple functions in early development by specifically binding to and inhibiting the function of BMP-2, -4, and -7. It also plays a role in carcinogenesis and kidney branching morphogenesis. Recombinant Gremlin-1 is a 13.7 kDa protein containing 160 amino acid residues.
NCBI Gene ID
26585
Swiss Prot
O60565
Accession Number
NP_001178251.1
Type
Recombinant Proteins
Source
CHO cells
Field of Research
Signal Transduction
Purity
Greater than 90% by SDS-PAGE gel and HPLC analyses.
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized Gremlin-1 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Gremlin-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Gremlin-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Gremlin 1, DAN family BMP antagonist
NCBI Organism
Homo sapiens
Other Product Names
DRM, HMPS, PIG2, CRAC1, DAND2, IHG-2, GREMLIN, CKTSF1B1, DRM, Gremlin-1, Cell proliferation-inducing gene 2 protein
Species
Human
Protein ID
300797307
Physical Properties
Lyophilized

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