IPO9 Antibody

• Background:

  Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity) . Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6.

• NCBI Gene ID:

  55705

• Swiss Prot:

  Q96P70

• Accession Number:

  Q96P70

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This IPO9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-106 amino acids from the N-terminal region of human IPO9.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  116 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  IPO9

• NCBI Official Name:

  Importin-9

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  King, F.W., et al. Mol. Cell. Biol. 24 (16) :7091-7101 (2004)

• Background Reference 02:

  Lubert, E.J., et al. Biochem. Biophys. Res. Commun. 303 (3) :908-913 (2003)

• Background Reference 03:

  Jakel, S., et al. EMBO J. 21 (3) :377-386 (2002)

• Background Reference 04:

  Muhlhausser, P., et al. EMBO Rep. 2 (8) :690-696 (2001)

• Other Product Names:

  Importin-9, Imp9, Ran-binding protein 9, RanBP9, IPO9, IMP9, KIAA1192, RANBP9

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  41688593

• Physical Properties:

  Liquid