IPO7 Antibody

• Background:

  The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.

• NCBI Gene ID:

  10527

• Swiss Prot:

  O95373

• Accession Number:

  O95373

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This IPO7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 142-169 amino acids from the N-terminal region of human IPO7.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  120 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  IPO7

• NCBI Official Name:

  Importin-7

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Huang, S., et al. Biosci. Rep. 30 (3) :159-168 (2010)

• Background Reference 02:

  Chachami, G., et al. Biochem. Biophys. Res. Commun. 390 (2) :235-240 (2009)

• Background Reference 03:

  Adeyemo, A., et al. PLoS Genet. (7), E1000564 (2009) :

• Background Reference 04:

  Zaitseva, L., et al. Retrovirology 6, 11 (2009) :

• Other Product Names:

  Importin-7, Imp7, Ran-binding protein 7, RanBP7, IPO7, RANBP7

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid