CD37 Antibody [IPO-24]

• Background:

  Recognizes a protein of 33-55kDa, identified as CD37 (Workshop V; Code CD37.7) . CD37 is strongly expressed on normal and neoplastic mature (sIg+) B-lymphocytes. In B-cell ontogeny, CD37 appears after the pre-B-cell stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells.1 CD37 is also present, at low densities, on resting and activated T cells, neutrophils, monocytes, and some myelomonocytic leukemia cells. It is absent from platelets, erythrocytes. CD37 is a member of a family of tetraspan transmembrane proteins, including CD9, CD53, CD63, CD81, and CD82. It associates other tetraspan transmembrane proteins and MHC class II molecules to form a large complex at the surface of B cells and play a role in signal transduction. CD37 is a valuable and stable marker for peripheral mature B-cells and corresponding malignancies like B-cell chronic lymphocytic leukemia (B-CLL), hairy cell leukemia (HCL), and all types of B-cell non-Hodgkin'' lymphoma (B-NHL) .

• NCBI Gene ID:

  951

• Swiss Prot:

  P11049

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Spleen cells from a patient with hairy cell leukemia were used as the immunogen for the CD37 antibody.

• Clonality:

  Monoclonal

• Clone:

  IPO-24

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  Protein G affinity chromatography

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG2b, kappa

• Symbol:

  CD37

• NCBI Official Name:

  CD37 molecule

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Leukocyte antigen CD37, Tetraspanin-26, Tspan-26, CD37, CD37, TSPAN26

• Tested Applications:

  WB, Functional Assays, Flow, IF

• Physical Properties:

  Liquid