FDPS Antibody

• Background:

  The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes.1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.

• NCBI Gene ID:

  2224

• Swiss Prot:

  P14324

• Accession Number:

  P14324

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This FDPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-112 amino acids from the N-terminal region of human FDPS.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  48 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  FDPS

• NCBI Official Name:

  Farnesyl pyrophosphate synthase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26) :16899-16903 (2002) .

• Background Reference 02:

  Nomura, N., et al., DNA Res. 1 (1) :27-35 (1994) .

• Background Reference 03:

  Wilkin, D.J., et al., J. Biol. Chem. 265 (8) :4607-4614 (1990) .

• Background Reference 04:

  Sheares, B.T., et al., Biochemistry 28 (20) :8129-8135 (1989) .

• Other Product Names:

  Farnesyl pyrophosphate synthase, FPP synthase, FPS, (2E,6E) -farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  215274250

• Physical Properties:

  Liquid