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FDPS Antibody

CAT: 0223-58-051Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-58-051Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
2224
Swiss Prot
P14324
Accession Number
P14324
Host
Rabbit
Reactivity
Human
Immunogen
This FDPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-82 amino acids from the N-terminal region of human FDPS.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
48 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
FDPS
NCBI Official Name
Farnesyl pyrophosphate synthase
NCBI Organism
Homo sapiens
Background Reference 01
Ishimoto, K., et al. Biochem. J. 429 (2) :347-357 (2010)
Background Reference 02
Choi, H.J., et al. Yonsei Med. J. 51 (2) :231-238 (2010)
Background Reference 03
Li, J., et al. J. Immunol. 182 (12) :8118-8124 (2009)
Background Reference 04
Romanelli, M.G., et al. Genomics 93 (3) :227-234 (2009)
Other Product Names
Farnesyl pyrophosphate synthase, FPP synthase, FPS, (2E,6E) -farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293
Tested Applications
WB
Protein ID
215274250
Physical Properties
Liquid

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C48149-01FDPS Antibody

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