FDPS Antibody

• Background:

  This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  2224

• Swiss Prot:

  P14324

• Accession Number:

  P14324

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This FDPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-82 amino acids from the N-terminal region of human FDPS.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  48 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  FDPS

• NCBI Official Name:

  Farnesyl pyrophosphate synthase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ishimoto, K., et al. Biochem. J. 429 (2) :347-357 (2010)

• Background Reference 02:

  Choi, H.J., et al. Yonsei Med. J. 51 (2) :231-238 (2010)

• Background Reference 03:

  Li, J., et al. J. Immunol. 182 (12) :8118-8124 (2009)

• Background Reference 04:

  Romanelli, M.G., et al. Genomics 93 (3) :227-234 (2009)

• Other Product Names:

  Farnesyl pyrophosphate synthase, FPP synthase, FPS, (2E,6E) -farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293

• Tested Applications:

  WB

• Protein ID:

  215274250

• Physical Properties:

  Liquid