FDPS Antibody

• Background:

  This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  2224

• Swiss Prot:

  P14324

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 120-419 of human FDPS (NP_001129293.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  293T

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 38kDa

• Fragment:

  IgG

• Symbol:

  FDPS

• Positive Control 2:

  HepG2

• Positive Control 3:

  HeLa

• Positive Control 4:

  MCF7

• Positive Control 5:

  U-251MG

• Positive Control 6:

  BxPC-3

• NCBI Official Name:

  Farnesyl pyrophosphate synthase

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Farnesyl pyrophosphate synthase, FPP synthase, FPS, (2E,6E) -farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid