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RAD21 Antibody

CAT: 0223-61-361Size: 200 µLDry Ice: NoHazardous: No
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CAT#:0223-61-361Size:200 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.
NCBI Gene ID
5885
Swiss Prot
O60216
Accession Number
O60216
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
This RAD21 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 501-535 amino acids from human RAD21.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
72 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:2000
Symbol
RAD21
NCBI Official Name
Double-strand-break repair protein rad21 homolog
NCBI Organism
Homo sapiens
Background Reference 01
McKay M.J., et al.Genomics 36:305-315 (1996) .
Background Reference 02
Sadano H., et al.Biochem. Biophys. Res. Commun. 267:418-422 (2000) .
Background Reference 03
Nomura N., et al.DNA Res. 1:223-229 (1994) .
Background Reference 04
Ota T., et al.Nat. Genet. 36:40-45 (2004) .
Other Product Names
Double-strand-break repair protein rad21 homolog, hHR21, Nuclear matrix protein 1, NXP-1, SCC1 homolog, RAD21, HR21, KIAA0078, NXP1
Tested Applications
WB
Physical Properties
Liquid

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