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COPS7B Antibody

CAT: 0223-61-356Size: 200 µLDry Ice: NoHazardous: No
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CAT#:0223-61-356Size:200 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
NCBI Gene ID
64708
Swiss Prot
Q9H9Q2
Accession Number
Q9H9Q2
Host
Rabbit
Reactivity
Human
Immunogen
This COPS7B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 61-95 amino acids from human COPS7B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
30 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:2000
Symbol
COPS7B
NCBI Official Name
COP9 signalosome complex subunit 7b
NCBI Organism
Homo sapiens
Background Reference 01
Ota T., et al.Nat. Genet. 36:40-45 (2004) .
Background Reference 02
Hillier L.W., et al.Nature 434:724-731 (2005) .
Background Reference 03
Mural R.J., et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Background Reference 04
Bech-Otschir D., et al.EMBO J. 20:1630-1639 (2001) .
Other Product Names
COP9 signalosome complex subunit 7b, SGN7b, Signalosome subunit 7b, JAB1-containing signalosome subunit 7b, COPS7B, CSN7B
Tested Applications
WB
Protein ID
55976598
Physical Properties
Liquid

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