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COPS5 Antibody

CAT: 0223-27-721Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-27-721Size:100 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by COPS5 is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.
NCBI Gene ID
10987
Swiss Prot
Q92905
Accession Number
NP_006828
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human COPS5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cancer
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store COPS5 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
38 kDa
Applications Notes
COPS5 antibody can be used for detection of COPS5 by ELISA at 1:62500. COPS5 antibody can be used for detection of COPS5 by western blot at 1.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
COPS5
NCBI Official Name
COP9 signalosome subunit 5
NCBI Organism
Homo sapiens
Background Reference 01
Oono, K., et al., (2004) Neurochem. Int. 45 (5), 765-772.
Other Product Names
COPS5, CSN5, JAB1, SGN5, MOV-34
Tested Applications
ELISA, WB, IHC
Protein ID
38027923
Physical Properties
Liquid

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