COPS5 Antibody

• Background:

  The protein encoded by COPS5 is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.

• NCBI Gene ID:

  10987

• Swiss Prot:

  Q92905

• Accession Number:

  NP_006828

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human COPS5.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription, Cancer

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. 1211 - HepG2 Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store COPS5 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  38 kDa

• Applications Notes:

  COPS5 antibody can be used for detection of COPS5 by ELISA at 1:62500. COPS5 antibody can be used for detection of COPS5 by western blot at 1.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  COPS5

• NCBI Official Name:

  COP9 signalosome subunit 5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Oono, K., et al., (2004) Neurochem. Int. 45 (5), 765-772.

• Other Product Names:

  COPS5, CSN5, JAB1, SGN5, MOV-34

• Tested Applications:

  ELISA, WB, IHC

• Protein ID:

  38027923

• Physical Properties:

  Liquid