COPS2 Antibody

• Background:

  COPS2 is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP. COPS2 is also innvolved in early stage of neuronal differentiation via its interaction with NIF3L1.

• NCBI Gene ID:

  9318

• Swiss Prot:

  P61201

• Accession Number:

  NP_004227

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Drosophila

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human COPS2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription, Cancer, Signal Transduction

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. XBL-10409 - Fetal Liver Tissue Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store COPS2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  51 kDa

• Applications Notes:

  COPS2 antibody can be used for detection of COPS2 by ELISA at 1:312500. COPS2 antibody can be used for detection of COPS2 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  COPS2

• NCBI Official Name:

  COP9 signalosome subunit 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Leal, J.F., (2008) Oncogene 27 (14), 1961-1970.

• Other Product Names:

  COPS2, ALIEN, CSN2, SGN2, TRIP15

• Tested Applications:

  ELISA, WB

• Protein ID:

  4759264

• Physical Properties:

  Liquid