COPS2 Antibody

• Background:

  COPS2 is an essential component of the COP9 signalosome complex (CSN) . The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. COPS2 is involved in early stage of neuronal differentiation via its interaction with NIF3L1.

• NCBI Gene ID:

  9318

• Swiss Prot:

  P61201

• Accession Number:

  NP_004227

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human COPS2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription, Cancer, Signal Transduction

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store COPS2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  52 kDa

• Applications Notes:

  COPS2 antibody can be used for detection of COPS2 by ELISA at 1:2500. COPS2 antibody can be used for detection of COPS2 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  COPS2

• NCBI Official Name:

  COP9 signalosome subunit 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Leal, J.F., (2008) Oncogene 27 (14), 1961-1970.

• Other Product Names:

  COPS2, ALIEN, CSN2, SGN2, TRIP15

• Tested Applications:

  ELISA, WB

• Protein ID:

  4759264

• Physical Properties:

  Liquid