TIGIT Antibody

• Background:

  Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

• NCBI Gene ID:

  201633

• Swiss Prot:

  Q495A1

• Accession Number:

  Q495A1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This TIGIT antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 12-142 amino acids from human TIGIT.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  26 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:2000

• Symbol:

  TIGIT

• NCBI Official Name:

  T-cell immunoreceptor with Ig and ITIM domains

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ota T., et al.Nat. Genet. 36:40-45 (2004) .

• Background Reference 02:

  Bechtel S., et al.BMC Genomics 8:399-399 (2007) .

• Background Reference 03:

  Yu X., et al.Nat. Immunol. 10:48-57 (2009) .

• Background Reference 04:

  Stengel K.F., et al.Proc. Natl. Acad. Sci. U.S.A. 109:5399-5404 (2012) .

• Other Product Names:

  T-cell immunoreceptor with Ig and ITIM domains, V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3, TIGIT, VSIG9, VSTM3

• Tested Applications:

  WB

• Protein ID:

  121943253

• Physical Properties:

  Liquid