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TIGIT Recombinant Protein

CAT: 0223-92-691Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-92-691Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
T cell immunoreceptor with Ig and ITIM domains (TIGIT), also called VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM), and is expressed on regulatory, memory, activated T cells and NK cells. TIGIT binds to CD155 (PVR) that appear on dendritic cells (DC), macrophages and endothelium with high affinity, and CD112 (PVRL2) with lower affinity, but not CD113 (PVRL3) . TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10, but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges, while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses.
CAS Number
9000-83-3
Swiss Prot
G7NXM4
Accession Number
G7NXM4
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Buffer
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
14.2 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Organism
Macaca fascicularis
Other Product Names
T-cell immunoreceptor with Ig and ITIM domains, VSIG9, VSTM3, TIGIT, V-set and transmembrane domain-containing protein 3, V-set and immunoglobulin domain-containing protein 9
Species
Cynomolgus monkey
Physical Properties
Lyophilized

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