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TIGIT Recombinant Protein

CAT: 0223-97-026Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-97-026Size:0.05 mg
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Background
T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3), which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM) . TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level) . TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
CAS Number
9000-83-3
NCBI Gene ID
100043314
Swiss Prot
NP_001139797
Accession Number
NP_001139797
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
40 kDa
Applications Notes
This recombinant protein can be used for E, WB. For research use only.
NCBI Official Name
T-cell immunoreceptor with Ig and ITIM domains precursor
NCBI Organism
Mus musculus
Background Reference 01
Yu X., et al., 2009, Nat. Immunol. 10:48-57.
Background Reference 02
Stengel K.F., et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109:5399-5404.
Background Reference 03
Lozano E., et al., 2012, J. Immunol. 188:3869-3875.
Other Product Names
TIGIT, VSIG9, VSTM3
Tested Applications
ELISA, WB
Species
Mouse
Physical Properties
Lyophilized

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