TIGIT Recombinant Protein

• Background:

  TIGIT (also called T cell immunoreceptor with Ig and ITIM domains) is one newly discovered immune receptor on some percentage of T cells and Natural Killer Cells (NK) . It is also identified as WUCAM and Vstm3. TIGIT could bind to CD155 (PVR) on dendritic cells (DCs), macrophages, etc. with high affinity, and also to CD112 (PVRL2) with lower affinity. TIGIT expressing CD8+ T cells has been shown to be expanded and associated with clinical markers of HIV disease progression in a diverse group of HIV infected individuals. TIGIT and PD-1 has been shown to be over expressed on tumor antigen-sepcific (TA-specific) CD8+ T cells and CD8+ tumor infiltrating lymphocytes (TILs) from individuals with melanoma. Blockade of TIGIT and PD-1 led to increased cell proliferation, cytokine production, and degranulation of TA-specific CD8+ T cells and TIL CD8+ T cells.

• NCBI Gene ID:

  201633

• Swiss Prot:

  Q495A1

• Accession Number:

  AAI01290

• Tag:

  Mouse IgG2a Fc tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Immunology

• Buffer:

  Tris with Glycine, Arginine and NaCl, pH7.5

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  40.1 kDa

• Applications Notes:

  This recombinant protein can be used for E, WB. For research use only.

• NCBI Official Name:

  T cell immunoreceptor with Ig and ITIM domains

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chew GM., et al., 2016, PLoS Pathogens., 12: e1005349.

• Background Reference 02:

  Joe-Marc Chauvin, et al., 2015, J Clin Invest., 125 (5) : 2046-2058.

• Background Reference 03:

  Steven G. Deeks, 2012, Nature, 487 (1) : 439-440.

• Other Product Names:

  TIGIT, VSIG9, VSTM3

• Tested Applications:

  ELISA, WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3