MLL3 Antibody

• Background:

  Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.

• NCBI Gene ID:

  58508

• Swiss Prot:

  Q8NEZ4

• Accession Number:

  Q8NEZ4

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MLL3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1142-1175 amino acids from the N-terminal region of human MLL3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  541 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For IHC-P starting dilution is: 1:25

• Symbol:

  KMT2C

• NCBI Official Name:

  Histone-lysine N-methyltransferase 2C

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ruault M., et al.Gene 284:73-81 (2002) .

• Background Reference 02:

  Tan Y.C., et al.Cancer Detect. Prev. 25:454-469 (2001) .

• Background Reference 03:

  Hillier L.W., et al.Nature 424:157-164 (2003) .

• Background Reference 04:

  Nagase T., et al.DNA Res. 7:143-150 (2000) .

• Other Product Names:

  Histone-lysine N-methyltransferase 2C, Lysine N-methyltransferase 2C, 2.1.1.43, Homologous to ALR protein, Myeloid/lymphoid or mixed-lineage leukemia protein 3, KMT2C, HALR, KIAA1506, MLL3

• Tested Applications:

  IHC-P

• Protein ID:

  221222521

• Physical Properties:

  Liquid