EPS15 Antibody

CAT: 0223-61-119Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-61-119Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
EPS15 is involved in cell growth regulation, possibly via the regulation of mitogenic signals and control of cell proliferation. EPS15 also participates in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Potential interaction partners include AP2A2, STN2, EPN1, and CRK via its SH3-binding sites. EPS15 is ubiquitously expressed. Phosphorylation on Tyr-849 is involved in the internalization of EGFR. EPS15 is not required for membrane translocation after EGF treatment or for targeting to coated pits, but essential for a subsequent step in EGFR endocytosis. This protein is involved in a t (1;11) (p32; q23) chromosomal translocation in acute leukemias causing fusion to the trithorax (MLL or HRX) gene product which contains DNA-binding motifs resulting in a rogue activator protein. Structurally, EPS15 contains 2 EF-hand calcium-binding domains, 3 EH domains, and 2 ubiquitin-interacting motif (UIM) repeats.
NCBI Gene ID
2060
Swiss Prot
P42566
Accession Number
P42566
Host
Rabbit
Reactivity
Human
Immunogen
This EPS15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 840-870 amino acids from the C-terminal region of human EPS15.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
99 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
EPS15
NCBI Official Name
Epidermal growth factor receptor substrate 15
NCBI Organism
Homo sapiens
Background Reference 01
De Beer, T., et al., Nat. Struct. Biol. 7 (11) :1018-1022 (2000) .
Background Reference 02
Enmon, J.L., et al., Biochemistry 39 (15) :4309-4319 (2000) .
Background Reference 03
De Beer, T., et al., Science 281 (5381) :1357-1360 (1998) .
Background Reference 04
Chen, H., et al., Nature 394 (6695) :793-797 (1998) .
Other Product Names
Epidermal growth factor receptor substrate 15, Protein Eps15, Protein AF-1p, EPS15, AF1P
Tested Applications
WB
Protein ID
67476728
Physical Properties
Liquid

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