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EPS15R Antibody

CAT: 0223-61-120Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-120Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Ubiquitin is a 76 amino acid highly conserved eukaryotic polypeptide that selectively marks cellular proteins for proteolytic degradation by the 26S proteasome. The process of target selection, covalent attachment and shuttle to the 26S proteasome is a vital means of regulating the concentrations of key regulatory proteins in the cell by limiting their lifespans. Polyubiquitination is a common feature of this modification. Serial steps for modification include the activation of ubiquitin, an ATP-dependent formation of a thioester bond between ubiquitin and the enzyme E1, transfer by transacylation of ubiquitin from E1 to the ubiquitin conjugating enzyme E2, and covalent linkage to the target protein directly by E2 or via E3 ligase enzyme. Deubiquitination enzymes also exist to reverse the marking of protein substrates. Posttranslational tagging by Ub is involved in a multitude of cellular processes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, stress responses, the immune response, and nervous system functions.
NCBI Gene ID
58513
Swiss Prot
Q9UBC2
Accession Number
Q9UBC2
Host
Rabbit
Reactivity
Human
Immunogen
This EPS15R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-216 amino acids from the N-terminal region of human EPS15R.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
94 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
EPS15L1
NCBI Official Name
Epidermal growth factor receptor substrate 15-like 1
NCBI Organism
Homo sapiens
Background Reference 01
J Biol Chem. 2002 Aug 23;277 (34) :30746-53.
Background Reference 02
J Biol Chem. 2002 Mar 15;277 (11) :8941-8.
Background Reference 03
J Biol Chem. 1998 Jan 30;273 (5) :3003-12.
Background Reference 04
Cancer Res. 1997 Dec 15;57 (24) :5498-504.
Other Product Names
Epidermal growth factor receptor substrate 15-like 1, Eps15-related protein, Eps15R, EPS15L1, EPS15R
Tested Applications
WB
Protein ID
61223942
Physical Properties
Liquid

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