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UBE2D1 Antibody

CAT: 0223-61-076Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-076Size:400 µL
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Background
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2D1 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.
NCBI Gene ID
7321
Swiss Prot
P51668
Accession Number
P51668
Host
Rabbit
Reactivity
Human
Immunogen
This UBE2D1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-140 amino acids from the C-terminal region of human UBE2D1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
17 kDa
Fragment
Rabbit Ig
Symbol
UBE2D1
NCBI Official Name
Ubiquitin-conjugating enzyme E2 D1
NCBI Organism
Homo sapiens
Background Reference 01
Bres, V., et al., Nat. Cell Biol. 5 (8) :754-761 (2003) .
Background Reference 02
Gehrke, S.G., et al., Blood 101 (8) :3288-3293 (2003) .
Background Reference 03
Kamura, T., et al., Proc. Natl. Acad. Sci. U.S.A. 97 (19) :10430-10435 (2000) .
Background Reference 04
Gutierrez, J.A., et al., Biochem. Biophys. Res. Commun. 253 (3) :739-742 (1998) .
Other Product Names
Ubiquitin-conjugating enzyme E2 D1, Stimulator of Fe transport, SFT, UBC4/5 homolog, UbcH5, Ubiquitin carrier protein D1, Ubiquitin-conjugating enzyme E2 (17) KB 1, Ubiquitin-conjugating enzyme E2-17 kDa 1, Ubiquitin-protein ligase D1, UBE2D1, SFT, UBC5A, UBCH5, UBCH5A
Tested Applications
WB, IHC-P
Protein ID
1717848
Physical Properties
Liquid

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