UBE2D1 Antibody

• Background:

  The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2D1 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.

• NCBI Gene ID:

  7321

• Swiss Prot:

  P51668

• Accession Number:

  P51668

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This UBE2D1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-140 amino acids from the C-terminal region of human UBE2D1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  17 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  UBE2D1

• NCBI Official Name:

  Ubiquitin-conjugating enzyme E2 D1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bres, V., et al., Nat. Cell Biol. 5 (8) :754-761 (2003) .

• Background Reference 02:

  Gehrke, S.G., et al., Blood 101 (8) :3288-3293 (2003) .

• Background Reference 03:

  Kamura, T., et al., Proc. Natl. Acad. Sci. U.S.A. 97 (19) :10430-10435 (2000) .

• Background Reference 04:

  Gutierrez, J.A., et al., Biochem. Biophys. Res. Commun. 253 (3) :739-742 (1998) .

• Other Product Names:

  Ubiquitin-conjugating enzyme E2 D1, Stimulator of Fe transport, SFT, UBC4/5 homolog, UbcH5, Ubiquitin carrier protein D1, Ubiquitin-conjugating enzyme E2 (17) KB 1, Ubiquitin-conjugating enzyme E2-17 kDa 1, Ubiquitin-protein ligase D1, UBE2D1, SFT, UBC5A, UBCH5, UBCH5A

• Tested Applications:

  WB, IHC-P

• Protein ID:

  1717848

• Physical Properties:

  Liquid