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FMO5 Antibody

CAT: 0223-60-965Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-965Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants.
NCBI Gene ID
2330
Swiss Prot
P49326
Accession Number
P49326
Host
Rabbit
Reactivity
Human
Immunogen
This FMO5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 474-502 amino acids from the C-terminal region of human FMO5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
60 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
FMO5
NCBI Official Name
Dimethylaniline monooxygenase [N-oxide-forming] 5
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Background Reference 02
Ross, C.J., et al. Nat. Genet. 41 (12) :1345-1349 (2009)
Background Reference 03
Wheeler, H.E., et al. PLoS Genet. (10), E1000685 (2009) :
Background Reference 04
Zhang, J., et al. Drug Metab. Dispos. 34 (1) :19-26 (2006)
Other Product Names
Dimethylaniline monooxygenase [N-oxide-forming] 5, Dimethylaniline oxidase 5, Hepatic flavin-containing monooxygenase 5, FMO 5, FMO5
Tested Applications
WB
Protein ID
1346021
Physical Properties
Liquid

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