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BMPR1B Antibody

CAT: 0223-60-848Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-848Size:400 µL
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Background
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
NCBI Gene ID
658
Swiss Prot
O00238
Accession Number
O00238
Host
Rabbit
Reactivity
Human
Immunogen
This BMPR1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 472-502 amino acids from the C-terminal region of human BMPR1B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Chicken
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
57 kDa
Fragment
Rabbit Ig
Symbol
BMPR1B
NCBI Official Name
Bone morphogenetic protein receptor type-1B
NCBI Organism
Homo sapiens
Background Reference 01
Kan, L. et al. Stem Cells.January; 27 (1) : 150?56 (2009) .
Background Reference 02
Lehmann, K., et al., Proc. Natl. Acad. Sci. U.S.A. 100 (21) :12277-12282 (2003) .
Background Reference 03
Astrom, A.K., et al., Mamm. Genome 10 (3) :299-302 (1999) .
Background Reference 04
Ide, H., et al., Oncogene 14 (11) :1377-1382 (1997) .
Other Product Names
Bone morphogenetic protein receptor type-1B, BMP type-1B receptor, BMPR-1B, CDw293, BMPR1B
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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