BMPR1A Antibody

• Background:

  The bone morphogenetic protein (BMP) receptors belong to a family of transmembrane serine/threonine kinases including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. Both activins and TGF-beta transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMP receptors are highly expressed in bone, skeletal muscle, heart and liver tissue. BMPRs play a crucial role during development as mutations or deletions to the BMPR genes can cause juvenile polyposis, disrupt normal dorsal/ventral patterning during limb development, and may be a factor in the progession of Cowden-like syndrome. Germline mutations in the BMPR2 gene encoding bone morphogenetic protein (BMP) type II receptor (BMPR-II) have been reported in patients with primary pulmonary hypertension (PPH) .

• NCBI Gene ID:

  657

• Swiss Prot:

  P36894

• Accession Number:

  P36894

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This BMPR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-51 amino acids from the N-terminal region of human BMPR1A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  60 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  BMPR1A

• NCBI Official Name:

  Bone morphogenetic protein receptor type-1A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zhou, X.-P., et al., Am. J. Hum. Genet. 69 (4) :704-711 (2001) .

• Background Reference 02:

  Howe, J.R., et al., Nat. Genet. 28 (2) :184-187 (2001) .

• Background Reference 03:

  Ten Dijke, P., et al., Oncogene 8 (10) :2879-2887 (1993) .

• Other Product Names:

  Bone morphogenetic protein receptor type-1A, BMP type-1A receptor, BMPR-1A, Activin receptor-like kinase 3, ALK-3, Serine/threonine-protein kinase receptor R5, SKR5, CD292, BMPR1A, ACVRLK3, ALK3

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  61252444

• Physical Properties:

  Liquid