BMPR2 Antibody

CAT: 0223-60-854Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-60-854Size:400 µL
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Background
BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension.
NCBI Gene ID
659
Swiss Prot
Q13873
Accession Number
Q13873
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This BMPR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-59 amino acids from the N-terminal region of human BMPR2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
115 kDa
Fragment
Rabbit Ig
Symbol
BMPR2
NCBI Official Name
Bone morphogenetic protein receptor type-2
NCBI Organism
Homo sapiens
Background Reference 01
Pouliot, F., et al., Cancer Res. 63 (2) :277-281 (2003) . Nishihara, A., et al., Mol. Biol. Cell 13 (9) :3055-3063 (2002) . Humbert, M., et al., Eur Respir20 (3) :518-523 (2002) . Vitt, U.A., et al., Biol. Reprod. 67 (2) :473-480 (2002) . Nohe, A., et al., J. Biol. Chem. 277 (7) :5330-5338 (2002) .
Other Product Names
Bone morphogenetic protein receptor type-2, BMP type-2 receptor, BMPR-2, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II, BMPR2, PPH1
Tested Applications
WB, IHC-P, Flow
Protein ID
12643724
Physical Properties
Liquid

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