BMPR2 Antibody

• Background:

  BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension.

• NCBI Gene ID:

  659

• Swiss Prot:

  Q13873

• Accession Number:

  Q13873

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This BMPR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-59 amino acids from the N-terminal region of human BMPR2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  115 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  BMPR2

• NCBI Official Name:

  Bone morphogenetic protein receptor type-2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Pouliot, F., et al., Cancer Res. 63 (2) :277-281 (2003) . Nishihara, A., et al., Mol. Biol. Cell 13 (9) :3055-3063 (2002) . Humbert, M., et al., Eur Respir20 (3) :518-523 (2002) . Vitt, U.A., et al., Biol. Reprod. 67 (2) :473-480 (2002) . Nohe, A., et al., J. Biol. Chem. 277 (7) :5330-5338 (2002) .

• Other Product Names:

  Bone morphogenetic protein receptor type-2, BMP type-2 receptor, BMPR-2, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II, BMPR2, PPH1

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  12643724

• Physical Properties:

  Liquid