BMPR1A Antibody

• Background:

  The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

• NCBI Gene ID:

  657

• Swiss Prot:

  P36894

• Accession Number:

  P36894

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This BMPR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-60 amino acids from the N-terminal region of human BMPR1A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  60 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  BMPR1A

• NCBI Official Name:

  Bone morphogenetic protein receptor type-1A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kan, L. et al. Stem Cells. January; 27 (1) : 150?56 (2009) . Waite, K.A., et al., Hum. Mol. Genet. 12 (6) :679-684 (2003) . Zhou, X.P., et al., Am. J. Hum. Genet. 69 (4) :704-711 (2001) . Astrom, A.K., et al., Mamm. Genome 10 (3) :299-302 (1999) . ten Dijke, P., et al., Oncogene 8 (10) :2879-2887 (1993) . Ide, H., et al., Cytogenet. Cell Genet. 81 (3-4), 285-286 (1998) .

• Other Product Names:

  Bone morphogenetic protein receptor type-1A, BMP type-1A receptor, BMPR-1A, Activin receptor-like kinase 3, ALK-3, Serine/threonine-protein kinase receptor R5, SKR5, CD292, BMPR1A, ACVRLK3, ALK3

• Tested Applications:

  WB, IHC-P

• Protein ID:

  61252444

• Physical Properties:

  Liquid