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PPM1F Antibody

CAT: 0223-60-805Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-805Size:400 µL
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Background
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.
NCBI Gene ID
9647
Swiss Prot
P49593
Accession Number
P49593
Host
Rabbit
Reactivity
Human
Immunogen
This PPM1F antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-303 amino acids from the Central region of human PPM1F.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
50 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PPM1F
NCBI Official Name
Protein phosphatase 1F
NCBI Organism
Homo sapiens
Background Reference 01
Harvey, B.P., et al. J. Biol. Chem. 279 (23) :24889-24898 (2004)
Background Reference 02
Koh, C.G., et al. Curr. Biol. 12 (4) :317-321 (2002)
Background Reference 03
Tan, K.M., et al. J. Biol. Chem. 276 (47) :44193-44202 (2001)
Background Reference 04
Kitani, T., et al. J. Biochem. 125 (6) :1022-1028 (1999)
Other Product Names
Protein phosphatase 1F, Ca (2+) /calmodulin-dependent protein kinase phosphatase, CaM-kinase phosphatase, CaMKPase, Partner of PIX 2, Protein fem-2 homolog, hFem-2, PPM1F, KIAA0015, POPX2
Tested Applications
WB
Protein ID
24638458
Physical Properties
Liquid

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