PPM1G Antibody

• Background :

  The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression.

• NCBI Gene ID :

  5496

• Swiss Prot :

  O15355

• Accession Number :

  O15355

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This PPM1G antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from the N-terminal region of human PPM1G.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Mouse

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  59 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  PPM1G

• NCBI Official Name :

  Protein phosphatase 1G

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Dick, D.M., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (6), 1179-1188 (2010) :

• Background Reference 02 :

  Suh, E.J., et al. Biochem. Biophys. Res. Commun. 386 (3) :467-470 (2009)

• Background Reference 03 :

  Petri, S., et al. J. Cell Biol. 179 (3) :451-465 (2007)

• Background Reference 04 :

  Allemand, E., et al. Nat. Struct. Mol. Biol. 14 (7) :630-638 (2007)

• Other Product Names :

  Protein phosphatase 1G, Protein phosphatase 1C, Protein phosphatase 2C isoform gamma, PP2C-gamma, Protein phosphatase magnesium-dependent 1 gamma, PPM1G, PPM1C

• Tested Applications :

  WB

• Physical Properties :

  Liquid