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YBX1 Antibody

CAT: 0223-60-802Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-802Size:400 µL
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Background
Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity) . Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as HLA class II genes. Regulates the transcription of numerous genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro) . May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability.
NCBI Gene ID
4904
Swiss Prot
P67809
Accession Number
P67809
Host
Rabbit
Reactivity
Human
Immunogen
This YBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-178 amino acids from the Central region of human YBX1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rabbit, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
36 kDa
Fragment
Rabbit Ig
Symbol
YBX1
NCBI Official Name
Nuclease-sensitive element-binding protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Yu, Y.N., et al. Int. J. Oncol. 37 (2) :483-492 (2010)
Background Reference 02
Lovett, D.H., et al. Biochem. Biophys. Res. Commun. 398 (3) :482-488 (2010)
Background Reference 03
Takahashi, M., et al. Cancer Sci. 101 (6) :1367-1373 (2010)
Background Reference 04
Cobbold, L.C., et al. Oncogene 29 (19) :2884-2891 (2010)
Other Product Names
Nuclease-sensitive element-binding protein 1, CCAAT-binding transcription factor I subunit A, CBF-A, DNA-binding protein B, DBPB, Enhancer factor I subunit A, EFI-A, Y-box transcription factor, Y-box-binding protein 1, YB-1, YBX1, NSEP1, YB1
Tested Applications
WB, IF
Protein ID
54040031
Physical Properties
Liquid

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