YBX1 Antibody

• Background:

  Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity) . Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as HLA class II genes. Regulates the transcription of numerous genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro) . May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability.

• NCBI Gene ID:

  4904

• Swiss Prot:

  P67809

• Accession Number:

  P67809

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This YBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-178 amino acids from the Central region of human YBX1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rabbit, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  36 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  YBX1

• NCBI Official Name:

  Nuclease-sensitive element-binding protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Yu, Y.N., et al. Int. J. Oncol. 37 (2) :483-492 (2010)

• Background Reference 02:

  Lovett, D.H., et al. Biochem. Biophys. Res. Commun. 398 (3) :482-488 (2010)

• Background Reference 03:

  Takahashi, M., et al. Cancer Sci. 101 (6) :1367-1373 (2010)

• Background Reference 04:

  Cobbold, L.C., et al. Oncogene 29 (19) :2884-2891 (2010)

• Other Product Names:

  Nuclease-sensitive element-binding protein 1, CCAAT-binding transcription factor I subunit A, CBF-A, DNA-binding protein B, DBPB, Enhancer factor I subunit A, EFI-A, Y-box transcription factor, Y-box-binding protein 1, YB-1, YBX1, NSEP1, YB1

• Tested Applications:

  WB, IF

• Protein ID:

  54040031

• Physical Properties:

  Liquid