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PSMD4 Antibody

CAT: 0223-60-767Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-767Size:400 µL
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Background
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21.
NCBI Gene ID
5710
Swiss Prot
P55036
Accession Number
P55036
Host
Rabbit
Reactivity
Human
Immunogen
This PSMD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-328 amino acids from the C-terminal region of human PSMD4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
41 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PSMD4
NCBI Official Name
26S proteasome non-ATPase regulatory subunit 4
NCBI Organism
Homo sapiens
Background Reference 01
Elangovan, M., et al. Biochem. Biophys. Res. Commun. 396 (2) :425-428 (2010)
Background Reference 02
Safadi, S.S., et al. J. Biol. Chem. 285 (2) :1424-1434 (2010)
Background Reference 03
Zhang, N., et al. Mol. Cell 35 (3) :280-290 (2009)
Background Reference 04
Kim, H.T., et al. EMBO J. 28 (13) :1867-1877 (2009)
Other Product Names
26S proteasome non-ATPase regulatory subunit 4, 26S proteasome regulatory subunit RPN10, 26S proteasome regulatory subunit S5A, Antisecretory factor 1, AF, ASF, Multiubiquitin chain-binding protein, PSMD4, MCB1
Tested Applications
WB
Protein ID
1709796
Physical Properties
Liquid

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