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PSME4 Antibody

CAT: 0223-61-210Size: 200 µLDry Ice: NoHazardous: No
CAT#:0223-61-210Size:200 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.
NCBI Gene ID
23198
Swiss Prot
Q14997
Accession Number
Q14997
Host
Rabbit
Reactivity
Human
Immunogen
This PSME4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 503-535 amino acids from human PSME4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
211 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:2000
Symbol
PSME4
NCBI Official Name
Proteasome activator complex subunit 4
NCBI Organism
Homo sapiens
Background Reference 01
Blickwedehl J., et al.Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
Background Reference 02
Nomura N., et al.DNA Res. 1:223-229 (1994) .
Background Reference 03
Ustrell V., et al.EMBO J. 21:3516-3525 (2002) .
Background Reference 04
Wang X., et al.Biochemistry 46:3553-3565 (2007) .
Other Product Names
Proteasome activator complex subunit 4, Proteasome activator PA200, PSME4, KIAA0077
Tested Applications
WB
Protein ID
134034993
Physical Properties
Liquid

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