PSMD5 Antibody

• Background :

  The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator base.

• NCBI Gene ID :

  5711

• Swiss Prot :

  Q16401

• Accession Number :

  Q16401

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This PSMD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 428-457 amino acids from the C-terminal region of human PSMD5.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  56 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  PSMD5

• NCBI Official Name :

  26S proteasome non-ATPase regulatory subunit 5

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Roelofs, J., et al. Nature 459 (7248) :861-865 (2009)

• Background Reference 02 :

  Kaneko, T., et al. Cell 137 (5) :914-925 (2009)

• Background Reference 03 :

  Listovsky, T., et al. EMBO J. 23 (7) :1619-1626 (2004)

• Background Reference 04 :

  Conticello, S.G., et al. Curr. Biol. 13 (22) :2009-2013 (2003)

• Other Product Names :

  26S proteasome non-ATPase regulatory subunit 5, 26S protease subunit S5 basic, 26S proteasome subunit S5B, PSMD5, KIAA0072

• Tested Applications :

  WB

• Protein ID :

  3122657

• Physical Properties :

  Liquid