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MBD2 Antibody

CAT: 0223-60-764Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-60-764Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD) . Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.
NCBI Gene ID
8932
Swiss Prot
Q9UBB5
Accession Number
Q9UBB5
Host
Rabbit
Reactivity
Human
Immunogen
This MBD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-279 amino acids from the Central region of human MBD2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
43 kDa
Fragment
Rabbit Ig
Symbol
MBD2
NCBI Official Name
Methyl-CpG-binding domain protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Liu, C.Y., et al. Carcinogenesis 31 (7) :1259-1263 (2010)
Background Reference 02
Guey, L.T., et al. Eur. Urol. 57 (2) :283-292 (2010)
Background Reference 03
Hosgood, H.D. III, et al. Respir Med 103 (12) :1866-1870 (2009)
Background Reference 04
McDonough, C.W., et al. Hum. Genet. (2009) In press :
Other Product Names
Methyl-CpG-binding domain protein 2, Demethylase, DMTase, Methyl-CpG-binding protein MBD2, MBD2
Tested Applications
WB, IF
Protein ID
50401198
Physical Properties
Liquid

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