MTHFR Antibody

• Background :

  The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.

• NCBI Gene ID :

  4524

• Swiss Prot :

  P42898

• Accession Number :

  P42898

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This MTHFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-292 amino acids from the Central region of human MTHFR.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Obesity, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Mouse

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  75 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  MTHFR

• NCBI Official Name :

  Methylenetetrahydrofolate reductase

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Singh, K., et al.Postgrad Med 56 (4) :267-269 (2010)

• Background Reference 02 :

  Harisha, P.N., et al.Neurosurg Pediatr 6 (4) :364-367 (2010)

• Background Reference 03 :

  Wu, H.C., et al. Anticancer Res. 30 (9) :3573-3577 (2010)

• Background Reference 04 :

  Magnowski, P., et al. Ginekol. Pol. 81 (7) :506-510 (2010)

• Other Product Names :

  Methylenetetrahydrofolate reductase, MTHFR

• Tested Applications :

  WB

• Protein ID :

  56405339

• Physical Properties :

  Liquid