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GATM Antibody

CAT: 0223-60-678Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-678Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by mental retardation, language impairment, and behavioral disorders.
NCBI Gene ID
2628
Swiss Prot
P50440
Accession Number
P50440
Host
Rabbit
Reactivity
Human
Immunogen
This GATM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 350-378 amino acids from the C-terminal region of human GATM.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Mouse, Pig, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
48 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
GATM
NCBI Official Name
Glycine amidinotransferase, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Kottgen, A., et al. Nat. Genet. 42 (5) :376-384 (2010)
Background Reference 02
Kottgen, A., et al. Nat. Genet. 41 (6) :712-717 (2009)
Background Reference 03
Lion-Francois, L., et al. Neurology 67 (9) :1713-1714 (2006)
Background Reference 04
Cullen, M.E., et al. Circulation 114 (1 SUPPL), I16-I20 (2006) :
Other Product Names
Glycine amidinotransferase, mitochondrial, L-arginine:glycine amidinotransferase, Transamidinase, GATM, AGAT
Tested Applications
WB
Protein ID
1730201
Physical Properties
Liquid

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