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Mouse Shc1 Antibody

CAT: 0223-60-641Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-641Size:400 µL
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Background
Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p47Shc and isoform p52Shc, once phosphorylated, couple activated receptor kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p47Shc and isoform p52 may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.
NCBI Gene ID
20416
Swiss Prot
P98083
Accession Number
P98083
Host
Rabbit
Reactivity
Mouse
Immunogen
This Mouse Shc1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 378-405 amino acids from the Central region of mouse Shc1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
63 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Shc1
NCBI Official Name
SHC-transforming protein 1
NCBI Organism
Mus musculus
Background Reference 01
Ursini-Siegel, J., et al. Cancer Res. 70 (20) :7776-7787 (2010)
Background Reference 02
Ma, Z., et al. Oncogene 29 (41) :5559-5567 (2010)
Background Reference 03
Fadini, G.P., et al. Diabetes 59 (9) :2306-2314 (2010)
Background Reference 04
Ranieri, S.C., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (30) :13420-13425 (2010)
Other Product Names
SHC-transforming protein 1, SHC-transforming protein A, Src homology 2 domain-containing-transforming protein C1, SH2 domain protein C1, Shc1, Shc, ShcA
Tested Applications
WB
Physical Properties
Liquid

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