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SHC1 Antibody

CAT: 0223-30-618Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-30-618Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SHC1 is a signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.
NCBI Gene ID
6464
Swiss Prot
P29353
Accession Number
NP_003020
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SHC1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Cancer, Signal Transduction, Immunology
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10410 - Fetal Lung Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store SHC1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
52 kDa
Applications Notes
SHC1 antibody can be used for detection of SHC1 by ELISA at 1:312500. SHC1 antibody can be used for detection of SHC1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
SHC1
NCBI Official Name
SHC (Src homology 2 domain containing) transforming protein 1
NCBI Organism
Homo sapiens
Background Reference 01
George, R., (2008) J. Mol. Biol. 377 (3), 740-747.
Other Product Names
SHC1, FLJ26504, SHC, SHCA, p52SHC, p66, p66SHC
Tested Applications
ELISA, WB
Protein ID
32261324
Physical Properties
Liquid

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