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Mouse Krt6a Antibody

CAT: 0223-60-661Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-661Size:400 µL
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Background
Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation related keratins) . Keratin 6 is found in hair follicles, neck squamous cell carcinomas, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyperproliferative situations. Epidermal injury results in activation of keratinocytes which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation. There are at least six isoforms of human type II keratin 6 (K6), K6A being the most abundant representing about 77% of all forms found in epithelia.
NCBI Gene ID
16687
Swiss Prot
P50446
Accession Number
P50446
Host
Rabbit
Reactivity
Mouse
Immunogen
This Mouse Krt6a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-240 amino acids from the Central region of mouse Krt6a.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
59 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Krt6a
NCBI Official Name
Keratin, type II cytoskeletal 6A
NCBI Organism
Mus musculus
Background Reference 01
Sehic, A., et al. Eur. J. Oral Sci. 117 (2) :93-104 (2009)
Background Reference 02
Chen, J., et al. J. Invest. Dermatol. 128 (2) :270-279 (2008)
Background Reference 03
Cui, C.Y., et al. Hum. Mol. Genet. 16 (21) :2583-2590 (2007)
Background Reference 04
Gu, L.H., et al. J. Invest. Dermatol. 127 (5) :1061-1073 (2007)
Other Product Names
Keratin, type II cytoskeletal 6A, Cytokeratin-6A, CK-6A, Keratin-6-alpha, mK6-alpha, Keratin-6A, K6A, Krt6a, Ker2, Krt2-6, Krt2-6a, Krt6
Tested Applications
WB
Physical Properties
Liquid

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