Mouse Krt6a Antibody

• Background :

  Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation related keratins) . Keratin 6 is found in hair follicles, neck squamous cell carcinomas, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyperproliferative situations. Epidermal injury results in activation of keratinocytes which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation. There are at least six isoforms of human type II keratin 6 (K6), K6A being the most abundant representing about 77% of all forms found in epithelia.

• NCBI Gene ID :

  16687

• Swiss Prot :

  P50446

• Accession Number :

  P50446

• Host :

  Rabbit

• Reactivity :

  Mouse

• Immunogen :

  This Mouse Krt6a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-240 amino acids from the Central region of mouse Krt6a.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  59 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  Krt6a

• NCBI Official Name :

  Keratin, type II cytoskeletal 6A

• NCBI Organism :

  Mus musculus

• Background Reference 01 :

  Sehic, A., et al. Eur. J. Oral Sci. 117 (2) :93-104 (2009)

• Background Reference 02 :

  Chen, J., et al. J. Invest. Dermatol. 128 (2) :270-279 (2008)

• Background Reference 03 :

  Cui, C.Y., et al. Hum. Mol. Genet. 16 (21) :2583-2590 (2007)

• Background Reference 04 :

  Gu, L.H., et al. J. Invest. Dermatol. 127 (5) :1061-1073 (2007)

• Other Product Names :

  Keratin, type II cytoskeletal 6A, Cytokeratin-6A, CK-6A, Keratin-6-alpha, mK6-alpha, Keratin-6A, K6A, Krt6a, Ker2, Krt2-6, Krt2-6a, Krt6

• Tested Applications :

  WB

• Physical Properties :

  Liquid