CB1 Antibody

• Background:

  This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq].

• NCBI Gene ID:

  1268

• Swiss Prot:

  P21554

• Accession Number:

  P21554

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-187 amino acids from the Central region of human CB1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Neuroscience, Signal Transduction, Growth Factors

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  53 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CNR1

• NCBI Official Name:

  Cannabinoid receptor 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Van Laere, K., et al. J. Nucl. Med. 51 (9) :1413-1417 (2010)

• Background Reference 03:

  Larrinaga, G., et al. Histol. Histopathol. 25 (9) :1133-1138 (2010)

• Background Reference 04:

  Monteleone, P., et al.Clin Psychopharmacol 30 (4) :441-445 (2010)

• Other Product Names:

  Cannabinoid receptor 1, CB-R, CB1, CANN6, CNR1, CNR

• Tested Applications:

  WB

• Protein ID:

  115562

• Physical Properties:

  Liquid