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CD16 Antibody [CB16] (FITC)

CAT: 0223-76-571Size: 25 TestsDry Ice: NoHazardous: No
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CAT#:0223-76-571Size:25 Tests
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The CB16 monoclonal antibody specifically reacts with human CD16, the low affinity IgG receptor III (FC gamma RIII) . CD16 is expressed on granulocytes, monocytes, macrophages, and NK cells and plays a role in NK activation and signal transduction. CD16 is expressed as either CD16a or CD16b. CD16a is a polypeptide-anchored transmembrane protein and CD16b is a glycosylphosphatidylinositol (GPI) -anchored protein that is expressed exclusively on neutrophils.
NCBI Gene ID
2214
Swiss Prot
P08637
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
CB16
Conjugation
FITC
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Fragment
Mouse IgG1, kappa
Specificity
The CB16 monoclonal antibody specifically reacts with human CD16, the low affinity IgG receptor III (FC gamma RIII) .
Symbol
FCGR3A
NCBI Official Name
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
NCBI Organism
Homo sapiens
Background Reference 01
Araujo-Jorge, T. A. N. I. A., Rivera, M. T., el Bouhdidi, A. Y. A. C. H. I., Daron, M. A. R. C., Carlier, Y. (1993) . An Fc gamma RII-, Fc gamma RIII-specific monoclonal antibody (2.4 G2) decreases acute Trypanosoma cruzi infection in mice.Infection and immunity,61 (11), 4925-4928.
Background Reference 02
Jensen, W. A., Marschner, S., Ott, V. L., Cambier, J. C. (2001) . FcgammaRIIB-mediated inhibition of T-cell receptor signal transduction involves the phosphorylation of SH2-containing inositol 5-phosphatase (SHIP), dephosphorylation of the linker of activated T-cells (LAT) and inhibition of calcium mobilization.Biochemical Society Transactions,29 (Pt 6), 840-846.
Background Reference 03
Vremec, D., Zorbas, M., Scollay, R., Saunders, D. J., Ardavin, C. F., Wu, L., Shortman, K. (1992) . The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells.The Journal of experimental medicine,176 (1), 47-58.
Other Product Names
CD16, FCG3, CD16A, FCGR3, IGFR3, IMD20, FCR-10, FCRIII, FCGRIII, FCRIIIA, FCGR3A
Tested Applications
Flow
Physical Properties
Liquid

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