CD16 Antibody [CB16]

• Background:

  The CB15 monoclonal antibody specifically binds to human CD16, a low affinity Fc receptor. It is expressed on NK, neutrophils, macrophages, monocytes, and placental trophoblasts. CD16 is expressed in CD16a and CD16b forms. CD16a is a polyeptide anchored transmembrane protein and CD16b is a monomeric glycosylphosphatidylinositol (GPI) -anchored protein found in neutrophils. CD16 is reported to be involved in NK cell activation and signal transduction.

• NCBI Gene ID:

  2214

• Swiss Prot:

  P08637

• Host:

  Mouse

• Reactivity:

  Human

• Clonality:

  Monoclonal

• Clone:

  CB16

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Innate Immunity

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C . Do not freeze.

• Fragment:

  Mouse IgG1

• Specificity:

  The CB15 monoclonal antibody specifically binds to human CD16, a low affinity Fc receptor.

• Symbol:

  FCGR3A

• NCBI Official Name:

  Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Deaglio, S., Zubiaur, M., Gregorini, A., Bottarel, F., Ausiello, C. M., Dianzani, U., ... Malavasi, F. (2002) . Human CD38 and CD16 are functionally dependent and physically associated in natural killer cells.Blood,99 (7), 2490-2498.

• Background Reference 02:

  Peruzzi, G., Femnou, L., Gil-Krzewska, A., Borrego, F., Weck, J., Krzewski, K., Coligan, J. E. (2013) . Membrane-type 6 matrix metalloproteinase regulates the activation-induced downmodulation of CD16 in human primary NK cells.The Journal of Immunology,191 (4), 1883-1894.

• Background Reference 03:

  Wirthmueller, U., Kurosaki, T., Murakami, M. S., Ravetch, J. V. (1992) . Signal transduction by Fc gamma RIII (CD16) is mediated through the gamma chain.The Journal of experimental medicine,175 (5), 1381-1390.

• Other Product Names:

  CD16, FCG3, CD16A, FCGR3, IGFR3, IMD20, FCR-10, FCRIII, FCGRIII, FCRIIIA, FCGR3A

• Tested Applications:

  Flow, Functional Assays

• Physical Properties:

  Liquid