EIF4E Antibody

• Background:

  EIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs. It is a 24-kD polypeptide that exists as both a free form and as part of a multiprotein complex termed EIF4F. The EIF4E polypeptide is the rate-limiting component of the eukaryotic translation apparatus and is involved in the mRNA-ribosome binding step of eukaryotic protein synthesis. The other subunits of EIF4F are a 50-kD polypeptide, termed EIF4A (see MIM 601102), that possesses ATPase and RNA helicase activities, and a 220-kD polypeptide, EIF4G.

• NCBI Gene ID:

  1977

• Swiss Prot:

  P06730

• Accession Number:

  P06730

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This EIF4E antibody is generated from rabbits immunized with a recombinant protein from human VGFR2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  25 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  EIF4E

• NCBI Official Name:

  Eukaryotic translation initiation factor 4E

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kim, S., et.al., J. Virol. 84 (1), 52-58 (2010)

• Background Reference 02:

  Kao, C.L., et.al., Cancer Lett. 286 (2), 250-259 (2009)

• Other Product Names:

  Eukaryotic translation initiation factor 4E, eIF-4E, eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein, EIF4E, EIF4EL1, EIF4F

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  1352435

• Physical Properties:

  Liquid