NEIL3 Antibody

• Background:

  NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]) .

• NCBI Gene ID:

  55247

• Swiss Prot:

  Q8TAT5

• Accession Number:

  Q8TAT5

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This NEIL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 292-320 amino acids from the Central region of human NEIL3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  68 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  NEIL3

• NCBI Official Name:

  Endonuclease 8-like 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Krokeide, S.Z., et al. Protein Expr. Purif. 65 (2) :160-164 (2009)

• Background Reference 02:

  Takao, M., et al. Genes Cells 14 (2) :261-270 (2009)

• Background Reference 03:

  Dallosso, A.R., et al. Gut 57 (9) :1252-1255 (2008)

• Background Reference 04:

  Bethke, L., et al. J. Natl. Cancer Inst. 100 (4) :270-276 (2008)

• Other Product Names:

  Endonuclease 8-like 3, 322-, DNA glycosylase FPG2, DNA glycosylase/AP lyase Neil3, Endonuclease VIII-like 3, Nei-like protein 3, NEIL3

• Tested Applications:

  WB

• Protein ID:

  302393810

• Physical Properties:

  Liquid