Mouse Sin3a Antibody

• Background :

  Sin3a acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3A to DNA. Acts as a corepressor for REST.

• NCBI Gene ID :

  20466

• Swiss Prot :

  Q60520

• Accession Number :

  Q60520

• Host :

  Rabbit

• Reactivity :

  Mouse

• Immunogen :

  This Mouse Sin3a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1078-1106 amino acids from the C-terminal region of mouse Sin3a.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Obesity

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Human

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  145 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  Sin3a

• NCBI Official Name :

  Paired amphipathic helix protein Sin3a

• NCBI Organism :

  Mus musculus

• Background Reference 01 :

  Baltus, G.A., et al. J. Biol. Chem. 284 (11) :6998-7006 (2009)

• Background Reference 02 :

  Anderson, D.M., et al. Dev. Dyn. 238 (3) :572-580 (2009)

• Background Reference 03 :

  Chang, S., et al. J. Immunol. 181 (12) :8372-8381 (2008)

• Background Reference 04 :

  Van Oevelen, C., et al. Mol. Cell 32 (3) :359-370 (2008)

• Other Product Names :

  Paired amphipathic helix protein Sin3a, Histone deacetylase complex subunit Sin3a, Transcriptional corepressor Sin3a, Sin3a, Kiaa4126

• Tested Applications :

  WB

• Physical Properties :

  Liquid