SIN3B Antibody

• Background:

  SIN3B acts as a transcriptional repressor. It interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities.It also interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. SIN3B also forms a complex with FOXK1 which represses transcription.

• NCBI Gene ID:

  23309

• Swiss Prot:

  O75182

• Accession Number:

  NP_056075

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SIN3B.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. XBL-10123 - Fetal Brain Tissue Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store SIN3B antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  133 kDa

• Applications Notes:

  SIN3B antibody can be used for detection of SIN3B by ELISA at 1:312500. SIN3B antibody can be used for detection of SIN3B by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  SIN3B

• NCBI Official Name:

  SIN3 transcription regulator family member B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Dhanda, R.S., (er) BMC Mol. Biol. 9, 8 (2008) .

• Other Product Names:

  SIN3B, KIAA0700

• Tested Applications:

  ELISA, WB

• Protein ID:

  52138513

• Physical Properties:

  Liquid