Mouse Cblb Antibody

CAT: 0223-60-393Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-60-393Size:400 µL
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Background
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization.
NCBI Gene ID
208650
Swiss Prot
Q3TTA7
Accession Number
Q3TTA7
Host
Rabbit
Reactivity
Mouse
Immunogen
This Mouse Cblb antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 862-889 amino acids from the C-terminal region of mouse Cblb.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
109 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Cblb
NCBI Official Name
E3 ubiquitin-protein ligase CBL-B
NCBI Organism
Mus musculus
Background Reference 01
Wilson, B.G., et al. Cancer Cell 18 (4) :316-328 (2010)
Background Reference 02
Stromnes, I.M., et al. J. Clin. Invest. 120 (10) :3722-3734 (2010)
Background Reference 03
Naramura, M., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (37) :16274-16279 (2010)
Background Reference 04
Teh, C.E., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (33) :14709-14714 (2010)
Other Product Names
E3 ubiquitin-protein ligase CBL-B, 632-, Casitas B-lineage lymphoma proto-oncogene b, SH3-binding protein CBL-B, Signal transduction protein CBL-B, Cblb
Tested Applications
WB
Physical Properties
Liquid

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