CBLC Antibody

• Background:

  Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed) . Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.

• NCBI Gene ID:

  23624

• Swiss Prot:

  Q9ULV8

• Accession Number:

  Q9ULV8

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CBLC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 424-453 amino acids from the C-terminal region of human CBLC.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  52 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CBLC

• NCBI Official Name:

  E3 ubiquitin-protein ligase CBL-C

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26) :16899-16903 (2002) .

• Background Reference 02:

  Keane, M.M., et al., Oncogene 18 (22) :3365-3375 (1999) .

• Background Reference 03:

  Kim, M., et al., Gene 239 (1) :145-154 (1999) .

• Other Product Names:

  E3 ubiquitin-protein ligase CBL-C, 632-, RING finger protein 57, SH3-binding protein CBL-3, SH3-binding protein CBL-C, Signal transduction protein CBL-C, CBLC, CBL3, RNF57

• Tested Applications:

  WB, IHC-P

• Protein ID:

  125987803

• Physical Properties:

  Liquid