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CBLB / RNF56 Recombinant Protein

CAT: 0223-11-318Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-11-318Size:0.1 mg
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Background
Casitas B-lineage lymphoma proto-oncogene b (CBLB) is also known as RNF56. E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle.
CAS Number
9000-83-3
NCBI Gene ID
868
Swiss Prot
Q13191
Accession Number
NP_733762.2
Tag
His Tag
Type
Recombinant Proteins
Source
E. coli
Purity
>95% as determined by SDS-PAGE.
Buffer
40 mM HEPES, 120 mM NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
47.0 kDa
Applications Notes
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 47.0 kDa. The protein migrates as 46 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
Cblproto-oncogeneB
NCBI Organism
Homo sapiens
Background Reference 01
Xiao Y., et al., 2015, J Immunol., 195 (9) : 4218-4227.
Background Reference 02
Desai SS., et al., 2015, J Biol Chem., 290 (42) : 25595-25608.
Background Reference 03
Van de Veerdonk FL., et al., 2016, Nat Med., 22 (8) : 834-835.
Other Product Names
CBL-B, CBLB, RNF56
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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